COMBINATION OF GEMCITABINE AND ANTI-PD-1 ANTIBODY ENHANCES THE ANTICANCER EFFECT OF M1 MACROPHAGES AND THE TH1 RESPONSE IN A MURINE MODEL OF PANCREATIC CANCER LIVER METASTASIS

Background Pancreatic ductular adenocarcinoma (PDAC) is among the most dreadful of malignancies, in part due to the lack of efficacious chemotherapy.Immune checkpoint inhibitors, including anti-programmed cell death 1 (anti-PD-1) antibodies, are novel promising forms of systemic immunotherapy.In the current study, we assessed whether gemcitabine (G

Objective: Meets the requirements of no overshoot in the response of the liquor blending control system, and eliminate the influence of system time lag on its control effect.Methods: An algorithm of liquor blending control based on variable universe fuzzy-Smith was proposed.Analyzed the control process and characteristics of the system and establis

Ensuring data confidentiality is a critical requirement for modern security systems globally.Despite the implementation of various access-control policies to enhance system security, significant threats persist due to insecure and inadequate access management.To address this, Multi-Party Authorization (MPA) systems employ multiple authorities for a

Interpretation of neural signals to a form that is as intelligible as speech facilitates the development of communication mediums for the otherwise speech/motor-impaired individuals.Speech perception, production, and imagination often constitute phases of human communication.The primary goal of this article is to analyze the similarity between thes

The transition of an increasing number of social relations into the virtual space and the intensive development of information technology is accompanied by the emergence of new illegal phenomena, in particular, of a criminal law nature, which requires appropriate legal regulation.Recently, the number of infringements on public relations in the fiel